Known primarily as a draughtsman and printmaker, Mundie's recent artistic output has concentrated on ink drawings, woodcuts, and photographs. Mundie's work has been exhibited widely at many locations, including: Center for Emerging Visual Artists (CFEVA), Federal Reserve Bank (Philadelphia), Pennsylvania Academy of the Fine Arts, University of Pennsylvania, Hunterdon Museum of Art, Kyoto Municipal Museum Annex, Pittsburgh Center for the Arts, Boston University, State Museum of Pennsylvania, and many others.

Drawings from the artist's provocative series Prodigies: Congress of Oddities have been exhibited at Stanek Gallery, Redux Contemporary Art Center, Yale University, The Free Library of Philadelphia, Samuel S. Fleisher Art Memorial, MF Gallery, Nexus: Foundation for Today's Art, Delaware Center for the Contemporary Arts, Perdue University, and Woodmere Art Museum, among others.

Mundie has received numerous awards for his work, including a Pennsylvania Council on the Arts fellowship. In 2007, Mundie received the Alumni Travel Grant from the Center for Emerging Visual Artists (CFEVA), which he used to visit anatomical collections in European museums. The photographs and drawings he produced there formed the basis of Cabinet of Curiosities, a series which continues to this day.

James Mundie is represented by Stanek Gallery. Mundie's work appears in the collections of The Book Arts Press, New York Public Library, Print Club of Albany, Spencer Museum of Art, Kyoto International Woodprint Association, University of Kentucky Art Museum, and others, including numerous private collections.

James Mundie resides in Philadelphia with fellow artist Kate Kern Mundie and their sons.